For which patient conditions is Methylergonovine contraindicated?

Methylergonovine is a medication primarily used to prevent or treat postpartum hemorrhage due to uterine atony. Its use is contraindicated in patients with preeclampsia or any form of cardiac disease because the drug acts as a vasoconstrictor and increases blood pressure. In individuals with compromised cardiovascular systems, such as those with preeclampsia (characterized by high blood pressure and potential organ dysfunction) or underlying cardiac conditions, using Methylergonovine could exacerbate their condition, leading to severe complications like hypertensive crises or myocardial ischemia.

Other conditions listed—such as gestational diabetes, severe asthma, and depression—do not present the same high risk associated with the vasoconstrictive properties of Methylergonovine. Therefore, while careful consideration and monitoring might be required for these conditions, they are not absolute contraindications for the use of the medication like cardiovascular disorders are. Understanding these contraindications is crucial for ensuring patient safety and effective management of postpartum care.